Michel L Tremblay Selected Research

Phosphoric Monoester Hydrolases (Phosphatases)

1/2021	Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
12/2019	Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4.
1/2019	Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
11/2018	Physiological and oncogenic roles of the PRL phosphatases.
1/2017	Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
7/2016	Localizing PRL-2 expression and determining the effects of dietary Mg(2+) on expression levels.
5/2015	Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.
4/2014	Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo.
8/2013	Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.
7/2013	On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.

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Michel L Tremblay Research Topics

Disease

34	Neoplasms (Cancer) 01/2021 - 05/2004
12	Obesity 09/2013 - 04/2002
11	Insulin Resistance 01/2015 - 02/2002
10	Inflammation (Inflammations) 11/2020 - 06/2008
8	Carcinogenesis 10/2020 - 02/2004
8	Breast Neoplasms (Breast Cancer) 10/2020 - 12/2009
7	Neoplasm Metastasis (Metastasis) 01/2017 - 03/2007
5	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 12/2007
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 01/2010
4	Prostatic Neoplasms (Prostate Cancer) 01/2016 - 01/2009
4	Weight Gain 01/2015 - 04/2002
4	Body Weight (Weight, Body) 01/2015 - 01/2010
3	Arthritis (Polyarthritis) 01/2020 - 03/2012
3	Rheumatoid Arthritis 01/2019 - 03/2012
3	Cachexia 02/2017 - 02/2012
3	Metabolic Diseases (Metabolic Disease) 09/2013 - 04/2010
3	Type 2 Diabetes Mellitus (MODY) 07/2010 - 06/2008
2	Cardiomegaly (Heart Hypertrophy) 01/2022 - 02/2008
2	Hypertrophy 01/2022 - 06/2012
2	Colitis 04/2018 - 01/2010
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2015 - 12/2011
2	Nephritis 09/2014 - 05/2004
2	Hypertension (High Blood Pressure) 11/2012 - 09/2009
2	Gliosis 03/2010 - 04/2005
2	Hypersensitivity (Allergy) 01/2010 - 07/2006
2	Leishmaniasis 09/2009 - 12/2007
2	Diabetes Mellitus 09/2009 - 02/2002
2	Infections 03/2009 - 12/2007
1	Kidney Neoplasms (Kidney Cancer) 07/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2021
1	Celiac Disease (Celiac Sprue) 01/2021
1	Immune System Diseases (Immune Disorders) 01/2021
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2021
1	COVID-19 12/2020
1	Encephalomyelitis (Myeloencephalitis) 10/2017
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 10/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2017
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2016
1	Pseudomonas Infections 01/2016
1	Leukemia 01/2016
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2016
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2016
1	Lymphoma (Lymphomas) 01/2016

Drug/Important Bio-Agent (IBA)

18	Protein Tyrosine PhosphatasesIBA 01/2021 - 12/2005
17	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 01/2009
15	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 01/2021 - 05/2004
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2004
12	Insulin (Novolin)FDA Link 01/2015 - 02/2002
11	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 01/2022 - 04/2002
11	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 12/2004
10	EnzymesIBA 01/2021 - 02/2004
8	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 01/2021 - 09/2009
6	CytokinesIBA 11/2020 - 12/2011
5	Pharmaceutical PreparationsIBA 03/2010 - 06/2008
4	Biomarkers (Surrogate Marker)IBA 10/2020 - 04/2009
4	LeptinIBA 03/2012 - 04/2002
3	Messenger RNA (mRNA)IBA 03/2016 - 01/2010
3	Janus KinasesIBA 01/2016 - 09/2009
3	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 11/2009
3	Class 2 Receptor-Like Protein Tyrosine PhosphatasesIBA 03/2010 - 04/2005
3	CortactinIBA 03/2009 - 06/2008
2	Phosphotransferases (Kinase)IBA 01/2021 - 01/2012
2	Small Interfering RNA (siRNA)IBA 01/2021 - 12/2004
2	Peptide Hydrolases (Proteases)FDA Link 03/2016 - 03/2009
2	Androgen Receptors (Androgen Receptor)IBA 02/2014 - 03/2012
2	Leptin ReceptorsIBA 09/2013 - 11/2012
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 06/2012 - 06/2012
2	Serine (L-Serine)FDA Link 03/2011 - 07/2009
2	Interleukin-6 (Interleukin 6)IBA 08/2010 - 01/2010
2	Hormones (Hormone)IBA 04/2010 - 04/2002
2	Insulin ReceptorIBA 11/2009 - 12/2005
1	MicroRNAs (MicroRNA)IBA 01/2022
1	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	Thyroid HormonesIBA 01/2022
1	Propylthiouracil FDA Link 01/2022
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2022
1	IsotopesIBA 07/2021
1	purineIBA 01/2021
1	Janus Kinase InhibitorsIBA 12/2020
1	Tight Junction ProteinsIBA 11/2020
1	Adenosine Triphosphatases (ATPase)IBA 10/2020
1	Tumor Necrosis Factor InhibitorsIBA 01/2020
1	Antirheumatic Agents (DMARD)IBA 01/2020
1	Dextrans (Dextran)FDA Link 04/2018
1	SodiumIBA 04/2018
1	Peptides (Polypeptides)IBA 10/2017
1	Interleukin-12 (IL 12)IBA 01/2017
1	Lapatinib (GW572016)FDA Link 12/2016
1	Tyrosine Kinase InhibitorsIBA 12/2016
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 12/2016
1	MagnesiumIBA 05/2016
1	Angiotensin IIIBA 03/2016
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2016
1	Proteoglycans (Proteoglycan)IBA 05/2015
1	Triglycerides (Triacylglycerol)IBA 01/2015
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2015
1	CholesterolIBA 01/2015

Therapy/Procedure

10	Therapeutics 01/2021 - 07/2008
1	Immunotherapy 01/2017